American Board ofKetamine Physicians

The complete clinical manual for ketamine practice.

After more than a decade running ketamine clinics and tens of thousands of administered doses, Dr. David Mahjoubi has compiled the protocols, dosing strategies, and operational discipline that distinguish a sustainable, high-outcome practice from one that merely runs infusions.

• 44 chapters across 9 parts — foundations and pharmacology, clinical indications, patient evaluation, IV and IM dosing protocols, at-home therapy, combination treatments, business and legal compliance, and chair-side quick-reference algorithms.
• Indication-specific dosing. Depression, anxiety, PTSD, chronic pain, alcohol use disorder, OCD, refractory headache, Ehlers-Danlos, and more — with the magnesium, midazolam, propofol, and adjunct decisions made explicit.
• At-home prescribing discipline. Nasal spray, troche, RDT, and sublingual dosing math through the 200 mg/day ceiling — including the concentration-conversion logic most prescribers get wrong.
• The regulatory scaffolding most guides ignore. DEA compliance, state board exposure, LegitScript certification, Google and Meta advertising policy — the operational substrate of a defensible practice.

Written for licensed physicians and ketamine clinic owners. The protocols and clinical positions in this manual reflect Dr. Mahjoubi's practice and a synthesis of the published literature; they are not a substitute for clinical judgment or applicable regulations in your jurisdiction.